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Description

Erastin acts by binding to VDAC2/3 on the external mitochondrial membrane, altering ion selectivity of the VDAC, so that the channel only permits cations to enter the mitochondria, retarding the oxidation of NADH, provoking mitochondrial dysfunction and oxidant release, and culminating in oxidation-dependent non-apoptotic cell death, now known as ferroptosis (Yagoda et al., 2007)

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Semaglutide is a Glucagon-Like Peptide-1 (GLP-1) agonist that historically has been used in helping patients with type 2 diabetes control their blood sugar

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