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Shikonin has also been shown to increase endogenous ROS levels and impair mitochondrial function, thereby enhancing its antifungal efficacy (Miao et al., 2012)
JAMA Psychiatry (2016) 73:878
These transcription factors are involved in the synthesis of several antioxidant enzymes (e.g., glutathione reductase, glutathione peroxidases, glutaredoxin, and glutathione- S -transferase), many of which are closely related to the cellular antioxidant, glutathione (Espinosa-Diez et al
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