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The SURPASS clinical trial programme, which evaluated tirzepatide's safety and efficacy across thousands of participants, did not identify peripheral neuropathy or paraesthesia as a significant adverse event attributable to the medication, as summarised in the European Medicines Agency's European Public Assessment Report (EPAR)
They included the metabolism of valine/leucine/isoleucine and cysteine/glutathione
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This suggests that the chemical modifications enhancing their stability may simultaneously limit their access to central GLP-1Rs
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