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Increased endocannabinoids inhibit monoacylglycerol lipase (Alhouayek et al., 2011), thereby reducing systemic inflammation, altering intestinal peptide secretion and increasing intestinal mucosal barrier thickness
Liraglutide monotherapy reduced body weight by 18.6% versus Vehicle
In a clinical study, Contrave reduced about 8% of body weight in participants after 56 weeks
Whilst semaglutide does not typically cause cognitive impairment, patients taking both medications should be monitored for any changes in mental function, particularly if topiramate doses are increased
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