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Results demonstrated 93% bacterial clearance four to 10 days after treatment versus 91% with standard intramuscular ceftriaxone plus oral azithromycin, meeting the non-inferiority endpoint and establishing gepotidacin as a legitimate single dose gonorrhea treatment alternative. Studies at the National Institutes of Health reveal that gepotidacin stabilizes DNA-enzyme complexes differently than fluoroquinolones, using mechanisms that circumvent established resistance pathways affecting other gonorrhea drugs

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