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NAC contains a highly reactive sulfhydryl group (SH), which gives it the direct ability to bind, or chelate, to certain heavy metals
Have practical assumptions
Pharmacological inhibition of cyclophilin D is only effective before this threshold is crossed, defining a narrow therapeutic window ( Together, these observations establish that perioperative mitochondrial dysfunction arises from the integrated action of ROS, RNS, Ca 2+ overload, and mPTP dynamicsnot ROS alone
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