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Reactive astrocytes as treatment targets in Alzheimers diseasesystematic review of studies using the APPswePS1dE9 mouse model

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Host-microbe interactions and network analysis As previously discussed, hostmicrobe interactions are crucial for maintaining skin immunity, barrier function, and overall homeostasis, and defending against pathogens

These short-lived senescent cells may initially enhance wound healing, but if allowed to persist, chronic senescence effects shift to a detrimental pro-inflammatory and proteolytic phenotype which limits regeneration [20,31]