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It is the most common route for musculoskeletal applications because it allows proximal injection near the injury site, which appears to improve local tissue concentration based on animal study findings
53 Additionally, biological assays determine whether they are agonistic or antagonistic compared to the most potent biologically active natural estrogen, 17-estradiol
GHK-Cu shows optimal effects at surprisingly low concentrations because at higher concentrations it also ramps up collagen-degrading enzymes
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