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Rather than sitting on the filtering cells of the nephron, the receptor is found mainly in the smooth muscle of the renal vasculature, so much of GLP-1s renal effect is hemodynamic and hormonal rather than a direct action on kidney tubules
Researchers commonly employ 50200 M final concentration, adjusted to cell-type sensitivity
With a half-life of approximately 7 days, semaglutide reaches what pharmacologists call "steady-state concentration" after 4 to 5 weeks of consistent weekly dosing
RDs find themselves counseling patients who are curious or take these medications and often are peppered with questions about their actions, side effects, and implications for short- and long-term use
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