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Multiple reviews and meta-analyses show that berberine supplementation can modestly improve fasting glucose, HbA1c, and other cardiometabolic markers across diverse adult populations.64 65 While its effects are not dramatic, theyre repeatable and biologically plausible, which is why berberine is often discussed alongside diet and lifestyle strategies for metabolic risk

These medications work by mimicking a natural hormone that helps regulate appetite, slow digestion, and balance blood sugar levels

The glucose-lowering efficacy measured by the decrease in HbA1c was dose-dependent in the tirzepatide group and did not plateau [52]

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