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Rather than creating a large caloric deficit through appetite suppression, sermorelin stimulates growth hormone production that gradually shifts the ratio of lean mass to fat mass

It achieved 16.2% weight loss at 52 weeks, with monthly or less frequent dosing

Explore Expanded Access If You Have Severe Complications If you have life-threatening obesity-related complications, are ineligible for clinical trials, and have exhausted all approved treatments, ask your physician to contact Eli Lilly at 1-800-545-5979 about expanded access

Until those results are published, all comparisons with semaglutide carry the caveat that retatrutide's data comes from a much smaller patient pool over a shorter timeframe