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His sister also died

2 Other GLP-1 medications, including another with semaglutide as a main active ingredient, do not list depression or suicidal ideation as potential side effects

Many of those patients regained a substantial portion of the weight they had lost, which underscores that obesity tends to behave as a chronic condition and that a long-term plan matters as much as the medication itself

Implications: As GLP-1 use expands, clinicians will need to balance substantial metabolic and cardiovascular benefits against a rare but potentially devastating eye risk while improving patient screening and symptom awareness