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In this review, detailed information on drug-induced kidney injury mechanisms and available in vitro models to predict this with relevant translational biomarkers will be discussed, with an emphasis on novel developments in the field of microphysiological systems that meet the requirements of the 3Rs (replacement, reduction, refinement) of animal experiments for drug safety screenings

Furthermore, AQ-QI- and DEAQ-QI-induced cytotoxicity was reduced in GSTP1 -transfected cells under GSH-depleted conditions

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A posted certificate of analysis does not replace a prescription, an appropriately licensed pharmacy, medical screening, accountable labeling and follow-up