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This process activates KCs in the liver, triggering the release of pro-inflammatory cytokines, including TNF- and IL-6, which exacerbate hepatocellular steatosis
Some studies, particularly in early disease stages or experimental models, indicate upregulation of SOD and CAT as a compensatory response to rising ROS [167]
FDA granted accelerated approval to resmetirom (Rezdiffra), a selective thyroid hormone receptor- (THR-) agonist, for the treatment of non-cirrhotic MASH
Both lowered SpO2 [26] and increased PBT [27] are indicants of the severity of the immune-inflammatory response of acute COVID-19, and both predict critical disease and mortality [27, 28]
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