is it normal to plateau on semaglutide The GLP-1 Plateau: What and How Get Past It Weight Loss Plateau on Semaglutide:

however, in the case of injury or disease, loss of NMNAT activity leads to NAD + depletion and NMN accumulation, which in turn activates SARM1 53,54,289

Many people start to notice weight loss within a few weeks, but the speed at which you lose weight will depend on a range of factors, including your starting weight, your daily habit changes (including changes to your calorie intake and how much physical activity you get), and other factors like any underlying conditions you might have

Advanced glycation end products (AGEs) exposure markedly impairs autophagic flux in renal TECs by activating the SMAD3/TFEB axis to suppress lysosome biogenesis and trigger lysosome depletion, leading to the accumulation of autophagosomes and SQSTM1/p62 ( Atg5 aggravates tubule injury and kidney damage, reflected as defective autophagy sensitized proximal TECs to ferroptosis (79)

If you are not able to reach your healthcare provider, you may need to find a local healthcare provider and get a prescription from them