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Side Effects and Safety Most common adverse effects include: Blue or green discoloration of urine and skin Nausea, vomiting, dizziness Confusion or serotonin syndrome (especially if combined with SSRIs) Hemolysis in patients with G6PD deficiency (contraindicated) It is generally well tolerated at low doses, but IV administration requires careful dosing due to risks of neurotoxicity and cardiac events at higher levels
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This effector immune mechanism involving cytokines has received extensive attention in APAP-induced hepatotoxicity, in which DAMPs released by damaged hepatocytes act on pattern recognition receptors (PRRs) on macrophages and other potential cells, causing the production of pro-inflammatory cytokines and chemokines, thus promoting the inflammatory response [173]
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