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Brilacidin (BRI), a synthetic small molecule that recapitulates the amphipathic architecture of HDPs, augments caspofungin (CAS) activity against Aspergillus fumigatus , Candida albicans , Candida auris , and CAS-resistant Cryptococcus isolates ( Another promising strategy involves combining antifungal agents with non-traditional pharmacological compounds

However, in immunocompromised individuals, conidia that escape clearance can persist, germinate, and initiate invasive infection (Margalit and Kavanagh, 2015

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