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The STEP 1 trial, published in the New England Journal of Medicine in 2021, showed that participants taking semaglutide 2.4 mg weekly lost an average of 14.9% of their body weight over 68 weeks, compared to 2.4% in the placebo group
Recommended Dosing Guide Start low and increase gradually to allow your body to adjust: Weeks 14: 2.5mg once weekly Weeks 58: 5mg once weekly Weeks 912: 7.5mg once weekly Week 13+: 10mg once weekly Adjust only when appetite suppression begins to decrease
Tirzepatide demonstrated that dual GIP/GLP-1 activation produced roughly 40% more weight loss than semaglutides GLP-1-only approach
It must be taken on an empty stomach with a small sip of water (no more than 120ml), followed by at least 30 minutes without food, drink or other oral medications
