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Titration refers to a gradual increase in dosage with a particular medication to allow the body time to get used to the medication until the target dose has been reached
Furthermore, ketamine alters key signaling pathways, such as the CaMKII-ERK1/2-CREB/NF-B axis, leading to reduced synaptic protein expression, synaptic plasticity impairment, and neurodegeneration (Luo et al., 2021)
These insights emphasize the complex and varied potential ways in which DSIP might impact sleep and stress, though further investigation is essential to fully delineate its biological functions and research potential
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