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In the first study, the Authors observed that GLP-1 levels were similar in PCOS and controls in the early phase of the 75-g oral glucose tolerance test (OGTT) until 60 min, but that GLP-1 levels were significantly lower after 180 min, suggesting that women with PCOS might have reduced GLP-1 secretion in the late postprandial phase [45]
TB-500 safety data in humans is limited to the wound healing trial, which reported no serious adverse events in the active treatment group 33
The claim that berberine is a "natural GLP-1 activator" equivalent to prescription medications is not supported by robust scientific evidence
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