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Gastro-intestinal symptoms score was assessed based on the score of Adam and collaborators 16 as follows: Parents were asked to indicate whether their children had experienced specific GI symptoms nausea, vomiting, bloating, abdominal cramps, early satiety, eructation or heartburn, loss of appetite, retrosternal discomfort and epigastric pain or abdominal pain over the past month

Furthermore, a combination of IGF-1R inhibitor (BMS-754807) and MEK inhibitor (U0126) significantly suppressed cell viability and colony formation in cultured cells (Fig

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Cell Mol Life Sci 74:15771603