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Relationship between low cardiorespiratory fitness and mortality in normal-weight, overweight, and obese men
[57] It achieves glycemic control primarily through a glucose-dependent mechanism: by binding to GLP-1 receptors on beta cells, it elevates intracellular levels of cyclic AMP (cAMP) and activates protein kinase A (PKA) and related signaling pathways
Among these, GLP-1RAs are able to reduce body weight (delaying gastric emptying and increasing satiety) and to reduce blood pressure (through reduction in body weight, but also trough increasing natriuresis and inducing vasodilation), as well as to improve microcirculation perfusion, endothelial function and lipid profile (reducing low-dense-lipoprotein and triglyceride-rich lipoproteins concentrations)
Dement Geriatr Cogn Disord 32:178181 Shin MC, Zhang J, Min KA, Lee K, Byun Y, David AE, He H, Yang VC (2014) Cell-penetrating peptides: achievements and challenges in application for cancer treatment
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