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Handling and use of these products should be restricted to suitably qualified professionals Additional information Pen instructions All pre-mixed cartridges are mixed with 2ml bacteriostatic water, pens will release approximately 0.5ml per 60 dials on the pen (one full pen) To achieve the number of micrograms (mcg) that 1 dial on the pen will release you will need to simply divide the amount of product: 2mg = 2000mcg 5mg = 5000mcg by the full amount of pen dials (which will always be 240) E.g., 5000mcg divided by 240 = 20.83, therefore 1 dial on the pen for all 5mg products will release approximately 20.83mcg

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Nasal route is generally lower-risk for such issues but care must still be taken with formulation, preservation, and absorption variability

Phase 2 trial (NEJM 2023) reported 24.2% mean weight loss at 48 weeks with 12 mg/week retatrutide, with gastrointestinal adverse events rising sharply at the 8 mg and 12 mg doses