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The findings of another prospective study (the Hordaland Health Study) that followed 7,045 healthy adults (ages, 47-49 years and 71-74 years) suggested that high choline and low betaine plasma concentrations were associated with an unfavorable cardiovascular risk profile (51)
T., Galenko, O., Garrett, K
Tein I, De Vivo DC, Bierman F et al : Impaired skin fibroblast carnitine uptake in primary systemic carnitine deficiency manifested by childhood carnitine-responsive cardiomyopathy
Reduced serum free carnitine as well as reduced levels of 3-keto-VPA, the main metabolite of -oxidation of VPA, was first reported in 1982 by Bohles and coworkers [53] in a 3-year-old girl who developed acute liver disease with typical features of Reye's syndrome after treatment with VPA for 6 months
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