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some preclinical and early research has suggested possible expression in skin-associated cells, though this evidence is not yet well established in humans and should be regarded as hypothesis-generating rather than confirmed

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51 A randomized placebo-controlled trial in 60 healthy older volunteers who received 400 mg of a lipid formulation providing 80 mg curcumin found the formulation improved attention and memory one hour later

Starting at a lower dose and gradually titrating upwards, as recommended in the prescribing information, can help minimise these effects