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AOD-9604 received FDA GRAS (Generally Recognized As Safe) status as a food ingredient in 2007, but this is not drug approval
Individuals with digestive conditions such as Crohns disease, celiac disease, or those whove undergone certain procedures affecting the stomach or small intestine may struggle with absorption
2000;279(3):E501-E507
Researchers confirmed this through knockout studies in mice, where animals lacking beta-3 adrenergic receptors showed zero response to AOD 9604, proving the peptide works specifically through this receptor pathway in adipose tissue
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