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The trial data shows the average climbing steadily over many months, which means a quiet stretch is usually just part of the curve rather than a sign of failure
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doi: 10.1016/j.ejphar.2024.177140 207 LiuZHuangTHongYYangYChenWZengQet al
If you are tolerating 8mg well and losing weight at a satisfactory rate, there is no clinical requirement to escalate further
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