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Oxidative stress promotes permeability of the blood-brain barrier: implications for the pathogenesis of Alzheimer's disease

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- Phase III: occurs 72-96 h after overdose, and coincides with the peak of hepatotoxicity, with transaminase elevations of up to 10,000 U / le and even higher, increases in bilirubin, glucose, lactate and phosphate, as well as elevated prothrombin time

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