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Contrave may also benefit patients who have coexisting mild depression or low motivation, although prescribing clinicians must carefully review mental health history to ensure that bupropion is appropriate

E -values, following VanderWeele and Dings approach, estimated the minimum strength of association needed by unmeasured confounders to fully explain observed associations, addressing potential biases from unmeasured confounding 53,54

The review also showed that taking vitamin C daily during winter months may reduce symptoms felt by 0.5 days, but there isnt enough data to conclusively say that vitamin C prevents colds (Hemila and Chalker 2013)

For a 220-pound hypothyroid patient, that translates to roughly 50 pounds