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Grossman Dr
The peptide is engineered with a fatty-acid moiety to extend its circulation time (half-life ~6 days), allowing for once-weekly dosing [2]
The transmembrane rather than paracellular transport of lipophilic compounds was supported by the demonstration of an inverse association between lipid/water partition coefficient and increased transport rate following calcium chelation, i.e., disrupting intercellular junctions increased the transport of hydrophilic but not of lipophilic small organic molecules [31]
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