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These metabolic shifts are part of why measurements taken during acute illness are interpreted with caution
The depressive brain has been shown to exhibit a decrease in hippocampal neurogenesis, and this reduction is recovered by antidepressant drug treatment (Tanti and Belzung, 2013)
Ng et al., Drug Development Research, 2000
Tirzepatide follows a dose-escalation protocol to minimize gastrointestinal side effects, starting at 2.5 mg once weekly and increasing by 2.5 mg increments every 4 weeks until reaching maintenance dose (515 mg weekly)
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