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Whilst the use of DPP-4 inhibitors may theoretically support weight loss in the treatment of obesity through increasing the half-life of endogenous GLP-1, weight loss associated with their use is clinically insignificant (0.160.64 kg) [29], and as such their use in obesity is not explored further in this manuscript

Semaglutide is a GLP-1 receptor agonist that helps with weight loss by suppressing appetite, reducing hunger signals, and slowing stomach emptying to prolong satiety

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Ding Y, Zhou YY, Chen H, Geng DD, Wu DY, Hong J, et al