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The knockout of ATM can also lead to an increase in H 2 O 2 within HSCs and induce excessive proliferation and differentiation of HSCs through the activation of the p38-MAPK pathway, ultimately leading to HSC exhaustion [294]
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telomerase activation may accelerate cancer cell growth in at-risk individuals, making it unsuitable for those with active cancer, pregnancy, breastfeeding, or children without specialist supervision
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