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For severely deconditioned patients or those with significant obesity-related mobility impairment, initiating injections first and adding exercise once initial weight loss improves functional capacity represents a reasonable staged approach

NMPA officials said in January that reviews of innovative therapies had accelerated, with 76 innovative drugs approved last year, up 58 per cent from 48 approvals in 2024

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Glucagon agonism can affect hepatic glucose output and lipid metabolism, and its long-term effects on liver function and cardiovascular risk require careful evaluation