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Fluid Retention and Heart Failure with Concomitant Use of PPAR-gamma Agonists: Fluid retention and heart failure can occur with concomitant use of thiazolidinediones (TZDs), which are PPAR-gamma agonists, and insulin, including NovoLog
Considering dopamines pivotal role in the brains reward system, such alterations could lead to an imbalance in dopaminergic neurotransmission 43,44
Cerebral micro-vessels are able to use both glucose and FAs as energy sources, a process seemingly driven by nutrient availability (Hingorani and Brecher, 1987)
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