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(12 August 2021)
[5] These include: Sildenafil (Viagra) Tadalafil (Cialis) Vardenafil (Levitra) Avanafil (Spedra) These medications work by enhancing the natural erectile response to sexual stimulation, increasing blood flow to the penis
The first requires the participation of the nicotinamide riboside kinases (NRKs) (Chi and Sauve, 2013) in two of its isoforms (NRK1 and NRK2) (Bieganowski and Brenner, 2004) and the second requires the action of purine nucleoside phosphorylase (PNP) and nicotinamide phosphoribosyltransferase (NAMPT) (Burgos et al., 2013) (Figure 2)
Existing studies have found that due to the influence of end-stage liver diseases such as cirrhosis, the inactivation of vasodilator factors in vivo is reduced, which leads to the dilation of visceral and peripheral arteries, the contraction of renal vessels, the reduction of glomerular filtration rate and the decrease of renal blood flow, and finally the occurrence of HRS (Sobhonslidsuk, 2015
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