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A separate 2025 narrative review by McGuire and colleagues asked a blunter question in its title: "Regeneration or Risk?" [2] Their conclusion: the preclinical evidence is consistently positive, but the absence of human data makes it impossible to generate evidence-based practice guidelines
however, these are diagnostic laboratory test interferences and not true drug interactions
High-dose B12 seems promising, mainly for those with a B12 deficiency or at risk
Dosages used in rodent studies range from 10mg/kg/day to 150mg/kg/day [1, 6, 11]
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