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They address different mechanisms of aging
3,3-Diindolylmethane inhibits VEGF expression through the HIF-1 and NF-B pathways in human retinal pigment epithelial cells under chemical hypoxic conditions
CAUTIONS: Safe use in pregnant animals or animals intended for breeding has not been proven
While historically listed with an "unknown status," recent data releases in late 2025 and early 2026 have clarified the safety profile that helped justify the Category 1 reclassification. Study Design: A randomized, placebo-controlled, double-blind Phase 1 pilot study
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