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At the same time, PDL1 nanoparticle treatment combined with the activation of the photosensitizer indocyanine green triggered by NIR laser irradiation can induce the production of reactive oxygen species thereby promoting CTLs infiltration into tumors and sensitizing tumors to PD-L1 blockade therapy and effectively inhibiting tumor growth and metastasis (180)
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Glutathione also participates in maintaining the redox state of protein thiol groups (sulfhydryl groups), which can influence protein structure, enzyme activity, and cellular signaling behavior under stress
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