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Individuals with BMI 30 kg/m, or Asians with BMI 2730 kg/m with obesity-related health issues Patients who are not surgical candidates or prefer to avoid surgery People who havent achieved results with lifestyle changes alone Bariatric Surgery: The Traditional Gold Standard Bariatric surgery (e.g., gastric bypass, sleeve gastrectomy) permanently changes the stomach and digestive system to promote substantial weight loss

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Interestingly, there have been a few reports suggesting a direct interaction between metformin and the incretin axis [79]

This protocol takes longer to show results but dramatically reduces the risk of adverse reactions