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Exceeding the upper reference range warrants dose reduction to avoid the theoretical risk of IGF-1-mediated proliferative effects documented with exogenous GH excess
reported that lower levels of TNF- and IL-8 could be observed after 5 weeks of IF (21)
(69) demonstrated that 14-day exposure to a eucaloric very-low-carbohydrate ketogenic diet as adjuvant treatment to first-generation somatostatin receptor ligands decreased IGF-I without increasing GH levels in acromegaly patients
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