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Chronic inflammation is probably the biggest driver, whether from gut infections like SIBO or candida, autoimmune conditions, or persistent immune activation
The nausea some patients experience may discourage fluid intake, and reduced eating often means reduced drinking too
Clinical studies All 23 relevant clinical studies for this section focused on the effects of GLP-1RAs on cardiometabolic parameters in people with schizophrenia-spectrum disorders on antipsychotics, apart from a secondary analysis investigating cognitive and mental health outcomes 133 (Table 3 and Extended Data Tables 3 and 4)
Hormone-sensitive lipase (HSL) in adipocytes is activated to produce the lipolytic effect, which is then enhanced by indirect processes such as secretion of growth hormone, cortisol, and adrenaline [39]
