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Additionally, some may experience weight loss initially but reach a plateau, unable to break through a specific weight threshold

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An earlier general systematic review on the neuroprotective role of GLP-1, which included both clinical and preclinical trials in PD, Alzheimers disease (AD), mood disorders, and other conditions, concludedbased on preclinical datathat GLP-1 has a substantial role in neuroprotection [62]

Rapid weight reduction itself triggers temporary decreases in bone mineral density, a physiological response that occurs with any significant caloric restriction