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Storage and handling requirements vary by compound class, format, and batch

SEC was performed by loading the protein onto Superose 6 Increase 10/300GL (GE Healthcare) column with running buffer containing 20 mM HEPES, pH 7.4, 100 mM NaCl, 10 mM MgCl 2 , 100 M TCEP, 5 M tirzepatide, 0.00075% (w/v) LMNG, 0.00025% (w/v) GDN, 0.0002% (w/v) CHS and 0.00025% digitonin (Anatrace)

If you experience persistent gastrointestinal discomfort throughout the week, your PlexusDx provider may recommend a slower dose escalation schedule or a microdose protocol, which delivers lower weekly amounts over an extended ramp-up period

Dynamic metabolic flux analysisTools for probing transient states of metabolic networks