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Several indicators suggest the need for dose adjustment

4,5,6 The term pernicious anaemia refers to an autoimmune disease that destroys the parietal cells, leading to a lack of IF and thus B12 deficiency

But, if they dont or get worse, its important to talk to a doctor

The human leukocyte antigen (HLA) region of chromosome 6 contains genes associated with an elevated risk of MS, including HLA-DR2 + , HLA-DQ6, DQA 0102, DQB1 0602, HLA-DRB1, DR15, DRB1*1501, and DRB1*1503