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However, this strategy is not universally effective, as the medication's long half-life means side effects can occur at any time during the week

, the raw values were subtracted from 10), resulting in final fatigue scores where 0 = no fatigue and 10 = maximal fatigue

Clinical trials, including SURPASS-2, have demonstrated significant improvements in HbA1c levels and substantial weight loss compared to other treatments, with effects becoming apparent within the first few weeks of treatment and continuing to improve over several months of consistent use

In several countries public payers are prohibited by statute from covering weight loss medications, for example in Germany, Italy and Medicare in the U.S