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The body has already adapted to substantial receptor activation

However, patients may experience: Allergic reactions presenting with urticaria (hives), pruritus (itching), or generalised rash Non-specific skin changes that may coincide with medication initiation but are not necessarily causally related Exacerbation of pre-existing skin conditions due to metabolic changes or stress It is worth noting that patients with diabetes are already at increased risk of various dermatological conditions, including bacterial and fungal infections, diabetic dermopathy, and other skin manifestations related to their underlying condition

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