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The AAFPs evidence-based clinical review states directly: Oral administration of high-dose vitamin B12 (1 to 2 mg daily) is as effective as intramuscular administration for correcting anemia and neurologic symptoms in patients with B12 deficiency (Langan RC, Goodbred AJ, American Family Physician, 2017)
Most published human research on the related full-length compound is in dry eye disease (under FDA-approved RGN-259 development), not on the TB-500 fragment per se
2020;80:592606.e8
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