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R PAPS is synthesized in two steps: ATP sulfurylase condenses ATP and inorganic sulfate to form adenosine-5'-phosphosulfate (APS), then APS kinase phosphorylates APS to form PAPS (at the cost of a second ATP)

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These findings emphasize the importance of antioxidants in managing various endocrine-related conditions ( 5.1 Natural antioxidants used in IBD therapy (polyphenols) Examples of the phytochemical family known as polyphenols present in many plant diets are flavonoids, phenolic acids, lignans, and stilbenes

Together, these findings identify the IFN-I- Chac2-GSH pathway as a key driver of systemic immune remodeling in periodontitis