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Am J Dis Child 141:10871089
Users stopping retinoids frequently report rapid regression of benefits within 4-8 weeks including increased breakouts sometimes exceeding pre-treatment levels (retinoid rebound), accelerated fine line reappearance approaching or surpassing baseline, skin texture deterioration returning to pre-treatment roughness, and psychological dependency from dramatic visible decline creating pressure for continuous use despite side effect burden
While this reaction was first found in individuals undergoing an antibiotic regime, other causes for a herx reaction include: Natural medicine regimens Dysbiosis- also known as an imbalance of the gut microbes Inflammation Detoxification process It is thought that this reaction is caused when bacteria dying off release toxins and cytokines
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